Several scientific studies have shown a greater efficacy of the 68Ga-PSMA tracer compared to the currently used gold standard, i.e. 18F-Choline.
The PSMA (Prostate Specific Membrane Antigen) is a transmembrane protein present in all tissues, mainly prostatic ones. A high level of PSMA is a wake-up call, since it indicates the transformation of prostatic cells into cancer cells. This makes PSMA a highly specific marker for prostate cancer.
Gallium-68 is a radioisotope which is used in diagnostic examinations for images such as PET / CT; it allows different body regions to be visualized with high specificity based on the ligand to which it is conjugated.
In the specific case of 68Ga-PSMA, the PET-CT measures the distribution of the radiopharmaceutical in the patient, thus allowing for a non-invasive evaluation of the PSMA value, in order to detect cancer and / or metastasis associated with it.
Afshar-Oromieh, Ali, et al. “Comparison of PET imaging with a 68 Ga-labeled PSMA ligand and 18 F-choline-based PET / CT for the diagnosis of recurrent prostate cancer.” European journal of nuclear medicine and molecular imaging 41.1 (2014): 11-20.
Fendler, Wolfgang P., et al. “68 Ga-PSMA PET / CT: Joint EANM and SNMMI procedures guideline for prostate cancer imaging: version 1.0.” European journal of nuclear medicine and molecular imaging 44.6 (2017): 1014-1024.